Tributylvinyltin → 2-Fluoro-4-vinylbenzonitrile

HRID 1246668노트

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HRID 1246668 반응식
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[CH:3]=1.[CH:11]([Sn](CCCC)(CCCC)CCCC)=[CH2:12]>C1(C)C=CC=CC=1>[F:10][C:4]1[CH:3]=[C:2]([CH:11]=[CH2:12])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

참가 물질

4

반응물 2

HCID 81998TributylvinyltinHCID 7360294-Bromo-2-fluorobenzonitrile

생성물 1

HCID 219046072-Fluoro-4-vinylbenzonitrile

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 4-bromo-2-fluorobenzonitrile (4.92 g, 0.0246 mol), vinyltributyltin (0.78 g, 0.246 mol), and tetrakistriphenylphosphine (0.67 g, 0.58 mmol) in 250 mL of toluene was refluxed under nitrogen overnight. The solvent was evaporated and the residue was flash chromatographed on silica gel with heptane:CH2Cl2 (1:1) to pure CH2Cl2. A colourless oil was obtained that crystallised. Yield: 3.0 g (82%).

후처리

  1. customThe solvent was evaporated
  2. customchromatographed on silica gel with heptane:CH2Cl2 (1:1) to pure CH2Cl2
  3. customA colourless oil was obtained
  4. customthat crystallised

출처 및 근거

ORD 기록
ord-cd9f1aea16614f398b75f57b875aba62
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129233B2

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