Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 1246717노트

반응식

HRID 1246717 반응식
C([N:8]1[CH2:13][CH2:12][C:11]([OH:18])([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[OH:18][C:11]1([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

참가 물질

4

반응물 1

HCID 12343427Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

생성물 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

Methyl 1-benzyl-4-hydroxy-4-piperidinecarboxylate in methanol was treated with Pd(OH)2 (20% on carbon, 500 mg) under a hydrogen atmosphere. The mixture was allowed to stir at room temperature for 12 hours, filtered, and the filtrate was concentrated under reduced pressure.

후처리

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a2744ea31a0944faae072d239330c164
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129235B2

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