Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminophenol → 1-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminophenol | HCID 403 | — |
| 반응물 | Maleic Anhydride | HCID 7923 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 1-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione | HCID 81734 | 33% |
반응 단계
The suspension that consists of 5.0 g (45.8 mmol) of 4-aminophenol, 4.49 g of maleic acid anhydride and 40 ml of acetic acid is refluxed for 3 hours. It is concentrated by evaporation, residual acetic acid is removed azeotropically by repeated distillation with acetic acid, and the residue is purified by chromatography on fine silica gel. 2.83 g (15.0 mmol, 33%) of the title compound is isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07129254B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-ac0e729cf46a477db6c37896c9c519a3 |
| 출처 메모 | uspto-grants-2006_10 |