Benzyl (S)-2-(7-methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylcarbamate → (S)-2-(7-Methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylamine

HRID 1247010노트

반응식

HRID 1247010 반응식
[CH3:1][O:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[N:13][N:14]([CH2:15][C@@H:16]([NH:18]C(=O)OCC4C=CC=CC=4)[CH3:17])[C:8]=3[C:6]=2[N:7]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[N:13][N:14]([CH2:15][C@@H:16]([NH2:18])[CH3:17])[C:8]=3[C:6]=2[N:7]=1

참가 물질

4

반응물 1

HCID 86604076Benzyl (S)-2-(7-methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylcarbamate

생성물 1

HCID 11988964(S)-2-(7-Methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of the product from Step E (60 mg, 0.157 mmol) in methanol (10 mL) was added 10% palladium-on-carbon (20 mg) and the mixture was stirred under an atmosphere of hydrogen at room temperature for 18 h. The reaction mixture was filtered and evaporated to a colorless oil (30 mg): LC/MS m/z 247.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customevaporated to a colorless oil (30 mg)

출처 및 근거

ORD 기록
ord-f32c1e8ecd9a49238595b28697e2b1d8
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129257B1

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