1-(Methylsulfonyl)-4-nitrobenzene → 4-(Methylsulfonyl)aniline

HRID 1247101노트

반응식

HRID 1247101 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3]>C1COCC1.C(O)C.[Pd]>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

참가 물질

5

반응물 1

HCID 2584341-(Methylsulfonyl)-4-nitrobenzene

생성물 1

HCID 796174-(Methylsulfonyl)aniline수율 91%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-(methylsulfonyl)nitrobenzene (6.26 g, 31.1 mmol) in THF (200 mL) and ethanol (100 mL) was placed in a high pressure reaction vessel and to this solution was added 5% Pd/C (1.6 g). The vessel was shaken for 8 h under an atmosphere of hydrogen (60 psi). The solution was then filtered through diatomaceous earth, partially concentrated in vacuo, and diluted with diethyl ether. The resulting precipitate was filtered and dried in vacuo to give 4.84 g (91%) of a tan solid.

후처리

  1. filtrationThe solution was then filtered through diatomaceous earth
  2. concentrationpartially concentrated in vacuo
  3. additiondiluted with diethyl ether
  4. filtrationThe resulting precipitate was filtered
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-975e039748e24067881a4baccd814c22
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129245B2

반응 노트

불러오는 중…