4-(Aminomethyl)benzonitrile → (RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide

반응식

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:12][CH3:13])[C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:14][CH2:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1>>[C:15]([C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH:21][C:9](=[O:11])[CH:8]([C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=2)[O:12][CH3:13])=[CH:18][CH:17]=1)#[N:14]

참가 물질

반응물 2

HCID 826084-(Aminomethyl)benzonitrile

HCID 189589752-(4-Hydroxyphenyl)-2-methoxyacetic acid

생성물 1

HCID 21905457(RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide

실험 절차

(RS)-(4-Hydroxy-phenyl)-methoxy-acetic acid was coupled with 4-aminomethyl benzonitrile according to general procedure B to give (RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide. Colorless foam. MS 295.2 ([M−H]−)

출처 및 근거

ORD 기록: ord-6e8d55ad75e646458fae5ede8c4e0991
출처 데이터셋: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07129238B2

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