(RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide → (RS)-N-(4-cyano-benzyl)-2-(4-ethoxy-phenyl)-2-methoxy-acetamide

HRID 1247260노트

반응식

HRID 1247260 반응식
[C:1]([C:3]1[CH:22]=[CH:21][C:6]([CH2:7][NH:8][C:9](=[O:20])[CH:10]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)[O:11][CH3:12])=[CH:5][CH:4]=1)#[N:2].[CH2:23](I)[CH3:24].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9](=[O:20])[CH:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:23][CH3:24])=[CH:15][CH:14]=2)[O:11][CH3:12])=[CH:21][CH:22]=1)#[N:2]

참가 물질

4

반응물 2

HCID 21905457(RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamideHCID 86593038Ethyl iodide cesium carbonate

생성물 1

HCID 21904945(RS)-N-(4-cyano-benzyl)-2-(4-ethoxy-phenyl)-2-methoxy-acetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In analogy to example 16.4, (RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide was alkylated with ethyl iodide/cesium carbonate in DMF to give (RS)-N-(4-cyano-benzyl)-2-(4-ethoxy-phenyl)-2-methoxy-acetamide as a colorless solid. MS 325.3 ([M+H]+)

출처 및 근거

ORD 기록
ord-ad7fb79c7cb84ca6ad55d45497ae8d30
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129238B2

반응 노트

불러오는 중…