4-Aminomethyl-2-fluoro-benzonitrile → HCID 21905716, 화합물

HRID 1247273

반응식

HRID 1247273 반응식
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]([O:14][CH3:15])[C:11]([OH:13])=O.[NH2:16][CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[C:20]([F:26])[CH:19]=1>>[C:22]([C:21]1[CH:24]=[CH:25][C:18]([CH2:17][NH:16][C:11](=[O:13])[CH:10]([C:3]2[CH:4]=[CH:5][C:6]([O:8][CH3:9])=[CH:7][C:2]=2[F:1])[O:14][CH3:15])=[CH:19][C:20]=1[F:26])#[N:23]

참가 물질

3

반응물 2

HCID 219046524-Aminomethyl-2-fluoro-benzonitrileHCID 67373142(RS)-(2-Fluoro-4-methoxy-phenyl)-methoxy-acetic acid

생성물 1

HCID 21905716HCID 21905716, 화합물

실험 절차

(RS)-(2-Fluoro-4-methoxy-phenyl)-methoxy-acetic acid (example 15.1) was coupled with 4-aminomethyl-2-fluorobenzonitrile (CAS 368426-73-7) according to general procedure B to give (RS)-N-(4-cyano-3-fluoro-benzyl)-2-(2-fluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Light yellow solid. MS 347.3 ([M+H]+)

출처 및 근거

ORD 기록
ord-b76a8235bc3042deaf0475d13b72f3f1
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129238B2

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