Methyl 2-Bromo-5-nitrobenzoate → Methyl 2-(2'-formylphenyl)-5-nitrobenzoate

HRID 1247494노트

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HRID 1247494 반응식
Br[C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1B(O)O)=[O:16]>>[CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])=[O:16]

참가 물질

3

반응물 2

HCID 245494Methyl 2-Bromo-5-nitrobenzoateHCID 2921892-Formylphenylboronic acid

생성물 1

HCID 21907645Methyl 2-(2'-formylphenyl)-5-nitrobenzoate

실험 절차

Methyl 2-bromo-5-nitrobenzoate was coupled to 2-formylphenylboronic acid using the procedure described for Example 4, Part A to provide methyl 2-(2′-formylphenyl)-5-nitrobenzoate. 1HNMR (300 MHz, CDCl3) δ 8.91 (s, 1H); 8.42 (d, 1H, J=8.5 Hz); 8.00 (d, 1H, J=8.5 Hz); 7.64 (m, 2H); 7.47 d, 1H, J=8.5 Hz); 7.22 (d, 1H, J=8.5 Hz); 3.71 (s, 3H).

출처 및 근거

ORD 기록
ord-35a88fcf307c4b61878dbd41bc97e8fd
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129264B2

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