m-Nitrophenethyl acetate → 2-(3-Aminophenyl)ethyl acetate
반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][O:12][C:13](=[O:15])[CH3:14])[CH:7]=[CH:8][CH:9]=1)([O-])=O>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][O:12][C:13](=[O:15])[CH3:14])[CH:7]=[CH:8][CH:9]=1참가 물질
4
실험 절차
To a solution of acetic acid 2-(3-nitro-phenyl)-ethyl ester (15 g, 71.7 mmol) (from Example 3a supra) in ethyl acetate (150 mL), was added 10% palladium on carbon (1.5 g) (Aldrich). This mixture was hydrogenated at room temperature on the Parr apparatus at 50 psi for one hour. The reaction mixture was filtered over a bed of Celite® and washed with ethyl acetate. The filtrate was concentrated under reduced pressure to give acetic acid 2-(3-amino-phenyl)-ethyl ester. (Yield 12.81 g, 71.48 mmol, 99%).
후처리
- filtrationThe reaction mixture was filtered over a bed of Celite®
- washwashed with ethyl acetate
- concentrationThe filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-cc969d9796c8474bba66811f7453b62b
- 출처 데이터셋
- uspto-grants-2006_10
- 특허 번호
- US07129351B2
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