Ethyl bromoacetate → Acetic acid, [[5′-(acetyloxy)[1,1′:3′,1′′-terphenyl]-2′-yl]oxy]-, ethyl ester

HRID 1247663노트

반응식

HRID 1247663 반응식
[C:1]([O:4][C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([OH:17])=[C:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=1)(=[O:3])[CH3:2].Br[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:1]([O:4][C:5]1[CH:6]=[C:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:8]([O:17][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:10]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 12544153HCID 12544153, 화합물

생성물 1

HCID 21907769Acetic acid, [[5′-(acetyloxy)[1,1′:3′,1′′-terphenyl]-2′-yl]oxy]-, ethyl ester수율 92%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 4acetoxy-2,6diphenylphenol (6.1 g, 20 mmol; prepared as described in Ber. 101, 2519 (1968)), ethyl bromoacetate )4.0 g, 24 mmol), potassium carbonate (3.3 g, 24 mmol) and 2-butanone (150 ml) was refluxed for 24 h, then filtered and the solvent evaporated. The residue was purified by chromatography on silica gel) 120 g, eluent benzene) to give 7.2 g (92%) of oily ethyl 4-acetoxy-2,6-diphenylphenoxyacetate.

후처리

  1. temperaturewas refluxed for 24 h
  2. filtrationfiltered
  3. customthe solvent evaporated
  4. customThe residue was purified by chromatography on silica gel) 120 g, eluent benzene)

출처 및 근거

ORD 기록
ord-9fc9c123cd1e4807a024448a20de85fd
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129268B2

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