Sulfuric Acid → HCID 69462687, 화합물

HRID 1247845노트

반응식

HRID 1247845 반응식
[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH2:9])=[C:7]([N:10]=O)[CH:6]=[N:5]1.[S:12](=[O:16])(=[O:15])([OH:14])[OH:13]>O.CO.[Pd]>[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH2:9])=[C:7]([NH2:10])[CH:6]=[N:5]1

참가 물질

6

반응물 2

HCID 1118Sulfuric AcidHCID 21904559HCID 21904559, 화합물

생성물 1

HCID 69462687HCID 69462687, 화합물수율 95.2%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of 1-(2-fluoroethyl)-4-nitroso-1H-pyrazol-5-amine (4.8 g) in water (30 ml) and methanol (30 ml) were added sulfuric acid (2.98 g) and 10% palladium on carbon (2.5 g), and the mixture was hydrogenated under balloon pressure for 7.5 hours. The reaction mixture was filtered through a bed of Celite, and the filtrate was concentrated in vacuo. 2-Propanol was added to the residue, and the precipitate was collected by filtration to give 1-(2-fluoroethyl)-1H-pyrazole-4,5-diamine sulfate (7 g).

후처리

  1. filtrationThe reaction mixture was filtered through a bed of Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. addition2-Propanol was added to the residue
  4. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-6ee5df7b411a4686ae13db1a89f61bf2
출처 데이터셋
uspto-grants-2006_10
특허 번호
US07129232B2

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