Water → N,1-dibutylhydrazinecarboxamide

HRID 1247872노트

반응식

HRID 1247872 반응식
O.Cl.[CH2:3]([NH:7][NH2:8])[CH2:4][CH2:5][CH3:6].[OH-].[K+].[CH2:11]([N:15]=[C:16]=[O:17])[CH2:12][CH2:13][CH3:14]>O1CCCC1>[CH2:11]([NH:15][C:16]([N:7]([CH2:3][CH2:4][CH2:5][CH3:6])[NH2:8])=[O:17])[CH2:12][CH2:13][CH3:14]

참가 물질

6

반응물 4

HCID 962WaterHCID 8110Butyl isocyanateHCID 14797Potassium HydroxideHCID 93308Butylhydrazine hydrochloride

생성물 1

HCID 19905055N,1-dibutylhydrazinecarboxamide수율 53.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a cooled (water bath), stirred mixture of 2.42 g n-butylhydrazine hydrochloride in 15 mL tetrahydrofuran was added 1.7 g powdered potassium hydroxide. The resulting mixture was stirred and maintained under a nitrogen atmosphere as n-butyl isocyanate (1.49 g, 0.015 moles) in 30 mL tetrahydrofuran was added dropwise. After addition, the solution was stirred overnight at ambient temperature. Work up as in Example 5 above yielded 1.5 g N,1-dibutylhydrazinecarboxamide b.p. 135°-6° C. at 0.08 torr, m.p. 34°-36° C. This structure was confirmed by NMR analysis.

후처리

  1. additionwas added 1.7 g
  2. stirringThe resulting mixture was stirred
  3. additionwas added dropwise
  4. additionAfter addition
  5. stirringthe solution was stirred overnight at ambient temperature

출처 및 근거

ORD 기록
ord-012f2365cc964bd4abf05aa31c506d23
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04521325

반응 노트

불러오는 중…