Ethanol → 2-Furanyl(7-phenylpyrazolo[1,5-a]pyrimidin-3-yl)methanone

HRID 1247964노트

반응식

HRID 1247964 반응식
[NH2:1][C:2]1[C:6]([C:7]([C:9]2[O:10][CH:11]=[CH:12][CH:13]=2)=[O:8])=[CH:5][NH:4][N:3]=1.[CH2:14](O)[CH3:15]>B(F)(F)F.CCOCC>[O:10]1[CH:11]=[CH:12][CH:13]=[C:9]1[C:7]([C:6]1[CH:5]=[N:4][N:3]2[C:13]([C:15]3[CH:14]=[CH:9][CH:7]=[CH:6][CH:5]=3)=[CH:12][CH:11]=[N:1][C:2]=12)=[O:8]

참가 물질

4

반응물 2

HCID 702EthanolHCID 178509268HCID 178509268, 화합물

생성물 1

HCID 134759012-Furanyl(7-phenylpyrazolo[1,5-a]pyrimidin-3-yl)methanone

시약·촉매·용매 1

HCID 8000Boron trifluoride etherate촉매

실험 절차

A mixture of 0.86 g of (3-amino-1H-pyrazol-4-yl)-2-furanylmethanone and 0.63 g of 1-phenyl-1-propynone in 35 ml of ethanol with several drops of boron trifluoride etherate was refluxed for 18 hours. The solvent was removed and the residue chromatographed on silica gel with ethyl acetate:hexane (1:20) as eluent and a gradual change to ethyl acetate:hexane (2:5). Elution with ethyl acetate gave a solid which was recrystallized from dichloromethanehexane, giving the desired product, mp 185°-187° C.

후처리

  1. temperaturewas refluxed for 18 hours
  2. customThe solvent was removed
  3. customthe residue chromatographed on silica gel with ethyl acetate:hexane (1:20) as eluent
  4. washElution with ethyl acetate
  5. customgave a solid which
  6. customwas recrystallized from dichloromethanehexane

출처 및 근거

ORD 기록
ord-14df1ce0d4b049c5bfa939f3ec9fb66c
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04521422

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