Acetone → 1,8-Cineole

HRID 1248037

반응식

HRID 1248037 반응식
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)O.[CH3:9][CH2:10][CH2:11]CCCC.[CH3:16]C(C)=O>>[CH3:9][C:10]1([CH3:11])[O:6][C:5]2([CH3:16])[CH2:7][CH2:8][CH:1]1[CH2:3][CH2:4]2

참가 물질

4

반응물 3

HCID 180AcetoneHCID 785Hydroquinone2회HCID 8900Heptane2회

생성물 1

HCID 27581,8-Cineole

실험 절차

Crystalline anhydrous hydroquinone (19.5 g) was added to a 1 cm diameter jacketed glass chromatography column filled with heptane. The heptane was then drained to the level of the top of the packed hydroquinone, cold acetone poured into the jacket to chill the column contents below -10° C., and Unitene-D (20 g) added. The column contents were then eluted with heptane (about 250 ml) with continued chilling over 2 hours. This removed most of the undesirable components of the feed. The jacket was then drained of coolant and the column warmed to room temperature. Continued elution with heptane provided a solution of 1.8-cineole (1.8 g) of 92.8% purity (solvent-free basis). This represents a 50% yield of 1,8-cineole present in the feedstock mixture.

후처리

  1. additionpoured into the jacket
  2. temperatureto chill the column contents below -10° C., and Unitene-D (20 g)
  3. additionadded
  4. washThe column contents were then eluted with heptane (about 250 ml)
  5. temperaturewith continued chilling over 2 hours
  6. customThis removed most of the undesirable components of the feed
  7. washContinued elution with heptane

출처 및 근거

ORD 기록
ord-1b1baecfde7746a2bb02cec0ef27caa0
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04521608

연결된 노트

불러오는 중…