N-benzyl-N-(5,6-dimethoxy-1-indanyl)glycine hydrochloride → N-(5,6-dimethoxy-1-indanyl)glycine

HRID 1248049노트

반응식

HRID 1248049 반응식
Cl.C([N:9]([CH:14]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH3:26][O:25][C:19]1[CH:18]=[C:17]2[C:22](=[CH:21][C:20]=1[O:23][CH3:24])[CH:14]([NH:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:15][CH2:16]2

참가 물질

4

반응물 1

HCID 20280785N-benzyl-N-(5,6-dimethoxy-1-indanyl)glycine hydrochloride

생성물 1

HCID 13472326N-(5,6-dimethoxy-1-indanyl)glycine수율 85.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

N-Benzyl-N-(5,6-dimethoxy-1-indanyl)glycine hydrochloride (14 g) is dissolved in 300 ml of ethanol, 3.0 g of 5% palladium-carbon is added and catalytic reduction is carried out at ordinary temperature and pressure. After absorption of the calculated amount of hydrogen, the catalyst is filtered off, and the ethanol is distilled off under reduced pressure. The residue is dissolved in 10 ml of water and adjusted to pH 7.0 with aqueous ammonia. The crystalline precipitates are collected by filtration, washed with a small amount of water, and dried, to give 8.0 g of N-(5,6-dimethoxy-1-indanyl)glycine as colorless needles. Melting point: 213°-216° C.

후처리

  1. customAfter absorption of the calculated amount of hydrogen
  2. filtrationthe catalyst is filtered off
  3. distillationthe ethanol is distilled off under reduced pressure
  4. dissolutionThe residue is dissolved in 10 ml of water
  5. customThe crystalline precipitates
  6. filtrationare collected by filtration
  7. washwashed with a small amount of water
  8. customdried

출처 및 근거

ORD 기록
ord-7e1aaa7c2056474abb958520d9448f26
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04521607

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