참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl chloroformate | HCID 6586 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 2-Phenylethanimidamide hydrochloride | HCID 12415514 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | methyl N-(2-phenylethanimidoyl)carbamate | HCID 140338859 | 93% |
반응 단계
137.2 parts of methyl chloroformate and a solution of 162.7 parts of potassium hydroxide in 180 parts of water are added via two inlets to a mixture of 246 parts of benzylmethanamidine hydrochloride in 530 parts of 1,2-dichloroethane and 85 parts of water, at from 10° to 15° C., in the course of 35 minutes. The mixture is stirred at 25° C. for 20 minutes, the organic phase is separated off and the aqueous phase is extracted twice more with 1,2- dichloroethane. The organic extracts are concentrated to give 259.8 parts (93% of theory) of N-methoxycarbonylbenzylmethanamidine of nD25 1.5247.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04522763 |
|---|
| 출처 데이터셋 | uspto-grants-1985_06 |
|---|
| ORD ID | ord-57f5e323111041c28e2a20ddf672fbf6 |
|---|
| 출처 메모 | uspto-grants-1985_06 |
|---|
