Indole, 3-(2-amino-2-methylpropyl)-5-bromo- → 3-(2-Amino-2-methylpropyl)-1H-indole-5-carbonitrile
반응식
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([NH2:15])([CH3:14])[CH3:13].[Cu](C#N)[C:17]#[N:18]>CN1CCCC1=O>[C:17]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([NH2:15])([CH3:14])[CH3:13])#[N:18]참가 물질
4
실험 절차
A mixture of 6.45 g of 2-(5-bromo 3-indolyl)1,1-dimethyl ethylamine and 3.25 g of copper cyanide in 40 ml of N-methylpyrrolidone is heated to reflux for 5 hours.
후처리
- temperatureis heated
- temperatureto reflux for 5 hours
출처 및 근거
- ORD 기록
- ord-c5214c132b2247d5adf30e2353f56d53
- 출처 데이터셋
- uspto-grants-1985_06
- 특허 번호
- US04522824
반응 노트
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