Indole, 3-(2-amino-2-methylpropyl)-5-bromo- → 3-(2-Amino-2-methylpropyl)-1H-indole-5-carbonitrile

HRID 1248109

반응식

HRID 1248109 반응식
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([NH2:15])([CH3:14])[CH3:13].[Cu](C#N)[C:17]#[N:18]>CN1CCCC1=O>[C:17]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]([NH2:15])([CH3:14])[CH3:13])#[N:18]

참가 물질

4

반응물 2

HCID 13259Indole, 3-(2-amino-2-methylpropyl)-5-bromo-HCID 178418260HCID 178418260, 화합물

생성물 1

HCID 140441343-(2-Amino-2-methylpropyl)-1H-indole-5-carbonitrile

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

A mixture of 6.45 g of 2-(5-bromo 3-indolyl)1,1-dimethyl ethylamine and 3.25 g of copper cyanide in 40 ml of N-methylpyrrolidone is heated to reflux for 5 hours.

후처리

  1. temperatureis heated
  2. temperatureto reflux for 5 hours

출처 및 근거

ORD 기록
ord-c5214c132b2247d5adf30e2353f56d53
출처 데이터셋
uspto-grants-1985_06
특허 번호
US04522824

연결된 노트

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