Thionyl Chloride → HCID 13476542, 화합물

반응식

O[CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15].S(Cl)([Cl:18])=O>>[Cl:18][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 13476541HCID 13476541, 화합물

생성물 1

HCID 13476542HCID 13476542, 화합물수율 86%

실험 절차

A mixture of 3.6 parts of 1-(2-hydroxyethyl)-2,4(1H,3H)-quinazolinedione and 40 parts of thionyl chloride is stirred and refluxed overnight. The reaction mixture is allowed to cool to room temperature. The precipitated product is filtered off, washed with 2,2'-oxybispropane and dried, yielding 3.4 parts (86%) of 1-(2-chloroethyl)-2,4-(1H,3H)-quinazolinedione; mp. 215.3° C.

후처리

temperaturerefluxed overnight
filtrationThe precipitated product is filtered off
washwashed with 2,2'-oxybispropane
customdried

출처 및 근거

ORD 기록: ord-1a33e088436b4181a4182c949eea4794
출처 데이터셋: uspto-grants-1985_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04522945

반응 노트

불러오는 중…