Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-(3-Pyridylmethyl)-4-pyrimidone → 2-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-(3-Pyridylmethyl)-4-pyrimidone | HCID 20448177 | — |
| 반응물 | 5-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine | HCID 21297583 | — |
| 생성물 | 2-[[4-[[5-[(Dimethylamino)methyl]-2-furanyl]methoxy]butyl]amino]-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone | HCID 20277884 | 52.2% |
반응 단계
A mixture of 5-[(4-aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine (1 g) and 2-methylthio)-5-[(3-pyridinyl)methyl]-4(3H)-pyrimidinone (1 g) was heated at 140° for 7 h. Column chromatography (silica/methanol) of the residue yielded the title compound (0.95 g) as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04524071 |
| 출처 데이터셋 | uspto-grants-1985_06 |
| ORD ID | ord-0641ff2f19e949608b077180c477192a |
| 출처 메모 | uspto-grants-1985_06 |