Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pentachlorophenol → N-t-butoxycarbonyl-leucyl-glycine-pentachlorophenyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pentachlorophenol | HCID 992 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | (S)-2-(2-((tert-Butoxycarbonyl)amino)-4-methylpentanamido)acetic acid | HCID 7018768 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-t-butoxycarbonyl-leucyl-glycine-pentachlorophenyl ester | HCID 18598487 | — |
반응 단계
In 300 ml of tetrahydrofuran were dissolved 40.0 g of N-t-butoxycarbonyl-leucyl-glycine and 38.8 g of pentachlorophenol, after which 30.0 g of dicyclohexylcarbodiimide (DCC) was added with ice-cooling, and the resulting mixture was subjected to reaction overnight. The insoluble material was collected by filtration and the solvent was removed by distillation to obtain a solid, which was recrystallized from ethyl acetate and petroleum ether to obtain N-t-butoxycarbonyl-leucyl-glycine-pentachlorophenyl ester. Yield: 65.9 g (88.5%). [α]D24 =-23.4° (C=1, dimethylformamide). Melting point (Mp): 155°-157° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04525576 |
| 출처 데이터셋 | uspto-grants-1985_06 |
| ORD ID | ord-aa12b83506844d798a7fe4b5d3b867a8 |
| 출처 메모 | uspto-grants-1985_06 |