Dichloromethane → 2-Difluoromethylthio-N-[N-(4,6-dimethoxy-1,3,3-triazin-2-yl)-N-methylaminocarbonyl]benzenesulfonamide

반응식

[CH3:1][O:2][C:3]1N=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][CH3:12])[N:4]=1.[F:13][CH:14]([F:28])[S:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22]([N:25]=[C:26]=[O:27])(=[O:24])=[O:23].[CH2:29](Cl)Cl>>[F:28][CH:14]([F:13])[S:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22]([NH:25][C:26]([N:11]([C:5]1[N:4]=[C:3]([O:2][CH3:1])[CH:29]=[C:7]([O:9][CH3:10])[N:6]=1)[CH3:12])=[O:27])(=[O:24])=[O:23]

참가 물질

반응물 3

HCID 6344Dichloromethane2회

HCID 350174,6-dimethoxy-N-methyl-1,3,5-triazin-2-amine

HCID 202259522-Difluoromethylthiobenzenesulfonyl isocyanate

생성물 1

HCID 202259612-Difluoromethylthio-N-[N-(4,6-dimethoxy-1,3,3-triazin-2-yl)-N-methylaminocarbonyl]benzenesulfonamide

실험 절차

To 0.80 g of 4,6-dimethoxy-2-methylamino-1,3,5-triazine in 25 ml of dry methylene chloride was added at ambient temperature 1.33 g of 2-difluoromethylthiobenzenesulfonyl isocyanate in 15 ml of methylene chloride. The reaction mixture was stirred for 16 hours and the resultant precipitate removed by filtration. It melted at 158°-164°, showed absorption peaks by Nuclear Magnetic Resonance (60MC) at: