Water → 4-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione

HRID 1248780

반응식

HRID 1248780 반응식
[S:1]1(=[O:12])(=[O:11])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3](=[O:10])[NH:2]1.FC(F)(F)C([O-])=[O:16].[Na+].O>FC(F)(F)C(O)=O>[OH:16][C:9]1[C:4]2[C:3](=[O:10])[NH:2][S:1](=[O:11])(=[O:12])[C:5]=2[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 5143SaccharinHCID 517019Sodium Trifluoroacetate

생성물 1

HCID 14865224-hydroxy-1H-1,2-benzisothiazole-1,1,3(2H)-trione수율 61%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

4.6 g (25 mmol) of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide (Saccharin®) were dissolved in 30 ml of trifluoroacetic acid and mixed with 4 g of sodium trifluoroacetate. The solution was electrolysed analogously to Example 1. After a charge quantity of 0.4 Ah had been used up the solution was added to water. It was extracted with chloroform and worked up as in Example 1. In addition to 3.3 g of starting material, 0.92 g of 4-hydroxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide were obtained after recrystallisation from water. This corresponds to a yield of 61% based on the starting material reacted;

후처리

  1. extractionIt was extracted with chloroform
  2. additionIn addition to 3.3 g of starting material

출처 및 근거

ORD 기록
ord-2a16ac6880be4a4eb206566ad2b4e1c3
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04626325

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