Methanesulfonic Acid → 8-Chloro-5-nitroacridine-2,9-diol

HRID 1248831노트

반응식

HRID 1248831 반응식
[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:17]CC4C=CC=CC=4)[CH:12]=3)[NH:7][C:6]=2[C:5]([N+:25]([O-:27])=[O:26])=[CH:4][CH:3]=1.CS(O)(=O)=O>C(O)(=O)C>[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[CH:12]=3)[NH:7][C:6]=2[C:5]([N+:25]([O-:27])=[O:26])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6395Methanesulfonic AcidHCID 135883221-Chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone

생성물 1

HCID 135882308-Chloro-5-nitroacridine-2,9-diol

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a stirred and boiling mixture of 26.7 g of 1-chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone in 1.9 l of glacial acetic acid was added 13.0 ml of methanesulfonic acid. Heating and stirring were continued for seven hours and the mixture was filtered. The precipitate was suspended in 250 ml of boiling glacial acetic acid, cooled to 60°, collected, washed with water and then methanol, and dried providing the title compound, mp above 325° C.

후처리

  1. temperatureHeating
  2. stirringstirring
  3. filtrationthe mixture was filtered
  4. temperaturecooled to 60°
  5. customcollected
  6. washwashed with water
  7. dry with materialmethanol, and dried

출처 및 근거

ORD 기록
ord-706d21d94aac4a13903d4d70fe288ebf
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04626540

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