Hydrazinecarboxaldehyde → 4-(3',5'-Difluorobenzyl)-1-formyl-3-thiosemicarbazide
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][N:6]=[C:7]=[S:8].[CH:13]([NH:15][NH2:16])=[O:14]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([F:12])[CH:11]=1)[CH2:5][NH:6][C:7](=[S:8])[NH:16][NH:15][CH:13]=[O:14]참가 물질
4
실험 절차
3,5-Difluorobenzyl isothiocyanate (9.9 g, 25.5 mmole) and formyl hydrazine (1.7 g, 28.7 mole) were refluxed in ethanol (30 ml) for one hour. The reaction was evaporated to dryness, triturated with hexane:ethyl acetate (1:1), filtered, and recrystallized from ethanol-hexane to yield 3.5 g (35%) of crude 4-(3',5'-difluorobenzyl)-1-formyl-3-thiosemicarbazide.
후처리
- customThe reaction was evaporated to dryness
- customtriturated with hexane:ethyl acetate (1:1)
- filtrationfiltered
- customrecrystallized from ethanol-hexane
출처 및 근거
- ORD 기록
- ord-4dc888b8db6742b1b616bfaa639e4d60
- 출처 데이터셋
- uspto-grants-1986_12
- 특허 번호
- US04628059
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