Acetic Acid → 3,3-Dimethyl-5-oxohexanoic acid

HRID 1248997

반응식

HRID 1248997 반응식
[O:1]=[C:2]1[CH2:9]C(C)(C)[CH2:5][C:4]([CH3:10])=[CH:3]1.[C:11]([OH:14])(=[O:13])[CH3:12]>>[O:1]=[C:2]([CH3:9])[CH2:3][C:4]([CH3:10])([CH3:5])[CH2:12][C:11]([OH:14])=[O:13]

참가 물질

3

반응물 2

HCID 176Acetic Acid2회HCID 6544Isophorone

생성물 1

HCID 113326103,3-Dimethyl-5-oxohexanoic acid

실험 절차

In a manner similar to that described in Example I, 30 grams isophorone in 57 grams aqueous acetic acid (35% H2O) was ozonized at ambient temperature and pressure in a 300 ml glass cylinder for approximately 5 1/2 hours. The resulting reaction product was then slowly dropped into a small amount of refluxing acetic acid, stripped at 140° C. under vacuum to remove water and acetic acid, and then vacuum distilled. Ninety-five percent yield of high purity 5-keto-3,3-dimethylhexanoic acid was obtained boiling in the range 96° C.-106° C. (0.1 mm Hg).

후처리

  1. customwas ozonized at ambient temperature
  2. customfor approximately 5 1/2 hours
  3. customThe resulting reaction product
  4. customstripped at 140° C. under vacuum
  5. customto remove water and acetic acid
  6. distillationvacuum distilled

출처 및 근거

ORD 기록
ord-20f90135b5c2457a938306c1e8b9ae9c
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04628117

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