Sulfuric Acid → HCID 178447982, 화합물

HRID 1249304노트

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HRID 1249304 반응식
[H-].C([Al+]CC(C)C)C(C)C.[CH2:11]([C@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][CH2:21][C@H:22]2[CH2:27][CH2:26][C@H:25]([C:28]#N)[CH2:24][CH2:23]2)[CH2:16][CH2:15]1)[CH2:12][CH3:13].S(=O)(=O)(O)[OH:31]>C1(C)C=CC=CC=1>[CH2:11]([C@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][CH2:21][C@H:22]2[CH2:27][CH2:26][C@H:25]([CH:28]=[O:31])[CH2:24][CH2:23]2)[CH2:16][CH2:15]1)[CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 21225700DiisobutylaluminumhydrideHCID 178447981HCID 178447981, 화합물

생성물 1

HCID 178447982HCID 178447982, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
0 °C

실험 절차

24 ml of a 1.2M solution of diisobutylaluminium hydride in toluene were added dropwise over a period of 30 minutes at 0° C. and under an inert gas atmosphere to a solution of 5.5 g of trans-4-[2-(trans-4-propylcyclohexyl)ethyl]cyclohexanecarbonitrile in 500 ml of toluene. The mixture was stirred at 0° C. for another hour and then at room temperature for 3 hours. The mixture was subsequently poured into 500 ml of 0.5N sulphuric acid and extracted three times with 200 ml of diethyl ether each time. The combined organic phases were washed first with saturated sodium hydrogen carbonate solution and then with water, dried over sodium sulphate and concentrated, thereby obtaining 5.6 g of trans-4-[2-(trans-4-propylcyclohexyl)ethyl]cyclohexanecarboxaldehyde.

후처리

  1. extractionextracted three times with 200 ml of diethyl ether each time
  2. washThe combined organic phases were washed first with saturated sodium hydrogen carbonate solution
  3. dry with materialwith water, dried over sodium sulphate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d590212cc2a348678932e23299701768
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04630896

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