alpha,alpha-Diphenyl-4-piperidineethanol → HCID 13754500, 화합물

HRID 1249565노트

반응식

HRID 1249565 반응식
[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(O)[CH2:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>FC(F)(F)C(O)=O>[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:8][CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 1

HCID 13754497alpha,alpha-Diphenyl-4-piperidineethanol

생성물 1

HCID 13754500HCID 13754500, 화합물수율 92%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

The title compound was prepared by dissolving 20 g of alpha,alpha-diphenyl-4-piperidineethanol in 40 mL of anhydrous trifluoroacetic acid and stirring for 15 minutes. The volatiles were removed under vacuum and the residue was partitioned between toluene and 2N sodium hydroxide solution. The organic layers were dried over sodium sulfate, evaporated, and the residue was crystallized from hexane to give 17.2 g (92%) of 4-(2,2-diphenylethenyl)piperidine, mp 98°-99° C. Anal. Calcd for C19H21N: C, 86.65; H, 8,.04; N, 5.32. Found: C, 86.35; H, 7.97; N, 5.26.

후처리

  1. customThe title compound was prepared
  2. customThe volatiles were removed under vacuum
  3. customthe residue was partitioned between toluene and 2N sodium hydroxide solution
  4. dry with materialThe organic layers were dried over sodium sulfate
  5. customevaporated
  6. customthe residue was crystallized from hexane

출처 및 근거

ORD 기록
ord-f51470da66eb4c81ad5361f4ed5153f9
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04632925

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