Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxylamine → 6-[1-Hydroxy-2-(N-tert-butylbenzylamino)ethyl]-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | N-(1,1-Dimethylethyl)benzenemethanamine | HCID 76908 | — |
| 반응물 | 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine | HCID 13748403 | — |
| 반응물 | 6-[1-hydroxy-2-(N-tert-butylbenzylamino)ethyl]pyridine | HCID 53930912 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 6-[1-Hydroxy-2-(N-tert-butylbenzylamino)ethyl]-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine | HCID 13340177 | — |
반응 단계
A solution of 33.0 g. (0.13 mole) 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino-[5,4-b]pyridine and 22.0 g. (0.135 mole) of N-tert-butylbenzylamine in 200 ml. of methanol was heated to the reflux temperature overnight. Upon cooling there deposited 6-[1- hydroxy-2-(N-tert-butylbenzylamino)ethyl]pyridine which was recrystallized from isopropanol to give 29.4 g. (54%) of the amino alcohol m.p. 126°-130° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04632992 |
| 출처 데이터셋 | uspto-grants-1986_12 |
| ORD ID | ord-e286de22e5854b9da3b1fae569df5f35 |
| 출처 메모 | uspto-grants-1986_12 |