Hydroquinone → 4-(2-Phenoxyethoxy)phenol

HRID 1249652노트

반응식

HRID 1249652 반응식
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[OH:2].Br[CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[OH-].[K+]>O>[OH:2][C:1]1[CH:8]=[CH:7][C:5]([O:6][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 785HydroquinoneHCID 14797Potassium HydroxideHCID 68526Benzene, (2-bromoethoxy)-

생성물 1

HCID 202239004-(2-Phenoxyethoxy)phenol수율 85%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 100 ml of water were added 40 g of hydroquinone, 20 g of β-bromophenetole and 6 g of potassium hydroxide and the mixture was subjected to reaction at 80° C. for about 2 hours. The solid precipitated was filtered and washed with warm water. The unreacted materials were extracted with alkali for removal. The remaining insoluble solids were removed by filtration and the filtrate was neutralized with hydrochloric acid. The solid precipited was filtered, washed with water and recrystallized from ethyl alcohol, giving 1-(4-hydroxyphenoxy)-2-phenoxy ethane in a yield of 85%. M.p. 156° C.

후처리

  1. customthe mixture was subjected to reaction at 80° C. for about 2 hours
  2. customThe solid precipitated
  3. filtrationwas filtered
  4. washwashed with warm water
  5. extractionThe unreacted materials were extracted with
  6. customalkali for removal
  7. customThe remaining insoluble solids were removed by filtration
  8. filtrationThe solid precipited was filtered
  9. washwashed with water
  10. customrecrystallized from ethyl alcohol

출처 및 근거

ORD 기록
ord-67459e8500044bd68a1439e84cfd80d7
출처 데이터셋
uspto-grants-1986_12
특허 번호
US04633277

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