2-methoxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one → 2-Methoxymethyl-3-benzyloxy-pyran-4(1H)-one

반응식

[CH3:1][O:2][CH2:3][C:4]1[O:5][C:6](C)=[CH:7][C:8](=[O:18])[C:9]=1[O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.OCC1OC=CC(=O)C=1OCC1C=CC=CC=1>>[CH3:1][O:2][CH2:3][C:4]1[O:5][CH:6]=[CH:7][C:8](=[O:18])[C:9]=1[O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 117473362-methoxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one

HCID 217925452-(Hydroxymethyl)-3-(phenylmethoxy)-4H-pyran-4-one

생성물 1

HCID 186788032-Methoxymethyl-3-benzyloxy-pyran-4(1H)-one수율 100%

실험 절차

In an analogous procedure in the preparation of 2-methoxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one using 2-hydroxymethyl-3-benzyloxy-pyran-4(1H)-one (2.32 g, 10 mmol, 1 eq.) yielded the title compound as an orange oil (2.5 g, ˜100%). Further purification by column chromatography on silica gel (eluant: EtOAc) furnished the pure product as a bright yellow oil.

출처 및 근거

ORD 기록: ord-2a1fea1969a34817abb518445c41f829
출처 데이터셋: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06335353B1

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