Water → 4'-(2,4,5-Triphenylimidazol-1-yimethyl)biphenyl-2-sulfonic Acid Dimethylaminomethylenamide

HRID 1250056

반응식

HRID 1250056 반응식
[C:1]1([C:7]2[NH:8][C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:24][N:25]([CH:27]=[N:28][S:29]([C:32]1[C:33]([C:38]2[CH:43]=[CH:42][C:41]([CH2:44]Br)=[CH:40][CH:39]=2)=[CH:34][CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30])[CH3:26].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[CH3:26][N:25]([CH:27]=[N:28][S:29]([C:32]1[C:33]([C:38]2[CH:39]=[CH:40][C:41]([CH2:44][N:11]3[C:10]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)=[C:9]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[N:8]=[C:7]3[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:42][CH:43]=2)=[CH:34][CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30])[CH3:24]

참가 물질

6

반응물 4

HCID 962WaterHCID 102322,4,5-TriphenylimidazoleHCID 11430Potassium CarbonateHCID 541617064'-Bromomethylbiphenyl-2-sulfonic acid dimethylaminomethylenamide

생성물 1

HCID 701445934'-(2,4,5-Triphenylimidazol-1-yimethyl)biphenyl-2-sulfonic Acid Dimethylaminomethylenamide수율 94.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.5 g of 2,4,5-triphenylimidazole, 1.9 g of 4′-bromomethylbiphenyl-2-sulfonic acid dimethylaminomethylenamide (J. Med. Chem. 1995, 38, 2357) and 2.1 g of K2CO3 are stirred at RT for 6 days in 50 ml of DMF. The reaction mixture is poured onto 300 ml of water and extracted with 500 ml of EA. The organic phase is washed 3 times with 250 ml of a saturated aqueous NaCl solution each time and dried over Na2SO4, and the solvent is removed in vacuo. 2.8 g of a viscous oil are obtained.

후처리

  1. extractionextracted with 500 ml of EA
  2. washThe organic phase is washed 3 times with 250 ml of a saturated aqueous NaCl solution each time
  3. dry with materialdried over Na2SO4
  4. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-ca350663db744ceca7bf4c0899855dd0
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06335451B1

연결된 노트

불러오는 중…