Water → HCID 70154017, 화합물

HRID 1250100노트

반응식

HRID 1250100 반응식
[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][OH:13])[CH:7]=1.[C:15]1([N:21]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22](Cl)=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.O>N1C=CC=CC=1>[CH3:1][O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][O:13][C:22](=[O:23])[N:21]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 65741N,N-Diphenylcarbamic chlorideHCID 21554300Acetic acid, 2-[3-(hydroxymethyl)phenoxy]-, methyl ester

생성물 1

HCID 70154017HCID 70154017, 화합물수율 73.5%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

(3-Hydroxymethylphenoxy)acetic acid methyl ester (400 mg, 2 mmol) and diphenylcarbamyl chloride (580 mg, 2.5 mmol) were combined in pyridine (2 ml). The resultant yellow solution was allowed to stand for ten days under nitrogen. The mixture was then poured into water, extracted with dichloromethane, and evaporated. Purification of the residue by silica gel chromatography, eluting with 5% acetone/dichloromethane, gave {3-[(diphenyl-carbamoyloxy)methyl]phenoxy}acetic acid methyl ester as a colorless solid (575 mg, 73%).

후처리

  1. waitto stand for ten days under nitrogen
  2. extractionextracted with dichloromethane
  3. customevaporated
  4. customPurification of the residue by silica gel chromatography
  5. washeluting with 5% acetone/dichloromethane

출처 및 근거

ORD 기록
ord-a032ae42ede2422c87a0821e26570e01
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06335459B1

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