Methyl 3-Coumarate → Methyl 3-(3-hydroxyphenyl)propionate
반응식
[CH3:1][O:2][C:3](=[O:13])/[CH:4]=[CH:5]/[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([OH:12])[CH:7]=1>[Pd].C(OCC)(=O)C>[CH3:1][O:2][C:3](=[O:13])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([OH:12])[CH:7]=1참가 물질
4
실험 절차
10% Palladium on carbon (0.31 g) was added to a solution of trans-3-(3-hydroxyphenyl)acrylic acid methyl ester (31.0 g, 17.4 mmol) (prepared as described in Example 6A) in ethyl acetate (30 mL) at room temperature under a nitrogen atmosphere. The mixture was hydrogenated under a balloon pressure for 4 hours. The catalyst was filtered, and the filtrate was concentrated to dryness. Crude 3-(3-hydroxyphenyl)propionic acid methyl ester (3.16 g) was directly used in the next step.
후처리
- filtrationThe catalyst was filtered
- concentrationthe filtrate was concentrated to dryness
출처 및 근거
- ORD 기록
- ord-cc8e888bd06a43008a0086783b8e6524
- 출처 데이터셋
- uspto-grants-2002_01
- 특허 번호
- US06335459B1
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