Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Azidomethyl-3-chlorobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4-(Bromomethyl)-3-chlorobenzonitrile | HCID 13042093 | — |
| 촉매 | Tetrabutylammonium hydrogen sulfate | HCID 94433 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-Azidomethyl-3-chlorobenzonitrile | HCID 22349974 | 100% |
반응 단계
A mixture 8.0 g (0.035 mol) of 4-bromomethyl-3-chlorobenzonitrile (J. Pharm. Sci., (1986) 75, 410), 2.7 g (0.042 mol) of sodium azide, 1.2 g (3.4 mmol) of tetrabutylammonium hydrogen sulfate, 0.30 g (3.4 mmol) of sodium hydrogen carbonate, 7 mL of water and 20 mL of toluene was stirred vigorously for 3 days. The phases were separated and the aqueous layer was extracted three times with ether. The combined organic phase was washed with water, dried over sodium sulfate and evaporated to give 6.7 g (100%) of the sub-title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06337394B2 |
| 출처 데이터셋 | uspto-grants-2002_01 |
| ORD ID | ord-86f1f9e530264254831e38a7faa488b4 |
| 출처 메모 | uspto-grants-2002_01 |