Trifluoroacetic acid → HCID 15516970, 화합물
반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:14]2[N:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[N:15]1[CH:16]=[CH:17][CH:18]=[N:19][C:14]=1[C:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=1참가 물질
4
실험 절차
500 mg of the compound of step 2 of Example 25 was dissolved in 10 ml of methylene chloride, 3.5 ml of trifluoroacetic acid (hereinafter referred to as TFA) was added, then the resultant mixture was agitated at room temperature for 30 minutes. This was concentrated, then an aqueous solution of 10% sodium hydroxide was added and extraction was performed with chloroform. The organic layer was washed by saturated saline and was dried with anhydrous magnesium sulfate. This chloroform was concentrated to obtain the above-referenced compound in an amount of 260 mg (yield of 87%).
후처리
- additionwas added
- concentrationThis was concentrated
- additionan aqueous solution of 10% sodium hydroxide was added
- extractionextraction
- washThe organic layer was washed by saturated saline
- dry with materialwas dried with anhydrous magnesium sulfate
- concentrationThis chloroform was concentrated
- customto obtain the above-referenced compound in an amount of 260 mg (yield of 87%)
출처 및 근거
- ORD 기록
- ord-113e3b6269224ed7a9aada12acbe05c7
- 출처 데이터셋
- uspto-grants-2002_01
- 특허 번호
- US06337397B1
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