Allylamine → 2-Allylamino-4-butylamino-6-nitroquinazoline

HRID 1250575노트

반응식

HRID 1250575 반응식
[CH2:1]([NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=2)[N:9]=[C:8](Cl)[N:7]=1)[CH2:2][CH2:3][CH3:4].[CH2:20]([NH2:23])[CH:21]=[CH2:22]>O>[CH2:20]([NH:23][C:8]1[N:7]=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=2)[N:9]=1)[CH:21]=[CH2:22]

참가 물질

4

반응물 2

HCID 7853AllylamineHCID 183264264-Butylamino-2-chloro-6-nitroquinazoline

생성물 1

HCID 183264552-Allylamino-4-butylamino-6-nitroquinazoline수율 82.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 170 mg (0.67 mmol) of 4-butylamino-2-chloro-6-nitroquinazoline was added 1.52 g (26.66 mmol) of allylamine, followed by stirring at room temperature overnight. To the reaction solution was water added, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 166 mg (yield: 82.1%) of the title compound.

후처리

  1. additionadded
  2. extractionfollowed by extraction with ethyl acetate
  3. washwashing with brine
  4. dry with materialdrying over anhydrous sodium sulfate
  5. distillationAfter the solvent was distilled off
  6. customthe residue was purified by a silica gel column

출처 및 근거

ORD 기록
ord-4c92adf3a733449299ce3d691aa61ce5
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06339089B2

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