Allylamine → 2-Allylamino-4-isopropylamino-6-nitroquinazoline hydrochloride

HRID 1250583

반응식

HRID 1250583 반응식
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:16]([O-:18])=[O:17])[CH:8]=2)[N:3]=1.[CH2:19]([NH2:22])[CH:20]=[CH2:21]>O>[ClH:1].[CH2:19]([NH:22][C:2]1[N:11]=[C:10]([NH:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:16]([O-:18])=[O:17])[CH:8]=2)[N:3]=1)[CH:20]=[CH2:21]

참가 물질

4

반응물 2

HCID 7853AllylamineHCID 183264282-Chloro-4-isopropylamino-6-nitroquinazoline

생성물 1

HCID 183265012-Allylamino-4-isopropylamino-6-nitroquinazoline hydrochloride

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 870 mg (3.26 mmol) of 2-chloro-4-isopropylamino-6-nitroquinazoline was added 3.81 g (66.64 mmol) of allylamine, followed by stirring at room temperature for 4 hours. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 895 mg (yield: 95.7%) of a free base compound of the title compound.

후처리

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing with brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by a silica gel column

출처 및 근거

ORD 기록
ord-3452785b83ad483896bc3e4eef052c71
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06339089B2

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