Water → 2-Chloro-7-methyl-4-neopentylaminothieno[3,2-d]pyrimidine

HRID 1250617

반응식

HRID 1250617 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=1.[CH2:13]([NH2:18])[C:14]([CH3:17])([CH3:16])[CH3:15].O>CN(C=O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:18][CH2:13][C:14]([CH3:17])([CH3:16])[CH3:15])[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 79882NeopentylamineHCID 71470642,4-Dichloro-7-methylthieno(3,2-d)pyrimidine

생성물 1

HCID 183264882-Chloro-7-methyl-4-neopentylaminothieno[3,2-d]pyrimidine수율 96.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 3 ml of DMF was dissolved 300 mg (1.4 mmol) of 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine, and after 179 mg (2.1 mmol) of neopentylamine was added to the resulting solution, the mixture was stirred for 3 hours. Water was added to the reaction mixture, and crystals thus precipitated were filtered to give 355 mg (yield: 96.1%) of the title compound.

후처리

  1. customthus precipitated
  2. filtrationwere filtered

출처 및 근거

ORD 기록
ord-112530ea9a734afe92f00877dace037a
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06339089B2

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