Allylamine → 2,4,7-Triallylaminothieno[3,2-d]pyrimidine

HRID 1250694노트

반응식

HRID 1250694 반응식
[CH2:1]([NH:4][C:5]1[N:6]=[C:7]([NH:15][CH2:16][CH:17]=[CH2:18])[C:8]2[S:13][CH:12]=[C:11](Br)[C:9]=2[N:10]=1)[CH:2]=[CH2:3].[CH2:19]([NH2:22])[CH:20]=[CH2:21].C(=O)([O-])[O-].[K+].[K+]>[Cu]>[CH2:1]([NH:4][C:5]1[N:6]=[C:7]([NH:15][CH2:16][CH:17]=[CH2:18])[C:8]2[S:13][CH:12]=[C:11]([NH:22][CH2:19][CH:20]=[CH2:21])[C:9]=2[N:10]=1)[CH:2]=[CH2:3]

참가 물질

5

반응물 3

HCID 7853AllylamineHCID 11430Potassium CarbonateHCID 183264202,4-Diallylamino-7-bromothieno[3,2-d]pyrimidine

생성물 1

HCID 183264232,4,7-Triallylaminothieno[3,2-d]pyrimidine수율 72.9%

시약·촉매·용매 1

HCID 23978Copper촉매

실험 절차

120 mg (0.37 mmol) of 2,4-diallylamino-7-bromothieno[3,2-d]pyrimidine, 337 mg (5.9 mmol) of allylamine, 56 mg (0.41 mmol) of potassium carbonate and 1 mg of copper were heated in a sealed tube at 180° C. for 5 hours. After completion of the reaction, the reaction mixture was allowed to resume room temperature, followed by distilling off excess allylamine under reduced pressure. The residue was purified by silica gel chromatography (eluent: ethyl acetate-hexane=1/8) to give 81 mg (yield: 72.9%) of the title compound.

후처리

  1. customAfter completion of the reaction
  2. customto resume room temperature
  3. distillationby distilling off excess allylamine under reduced pressure
  4. customThe residue was purified by silica gel chromatography (eluent: ethyl acetate-hexane=1/8)

출처 및 근거

ORD 기록
ord-94761747e999438f8e52170d0b8bc2f7
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06339089B2

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