2-{3-[(3-Morpholinopropyl)amino]-3-oxopropyl}phenyl N-octadecylcarbamate → HCID 18520278, 화합물

HRID 1250767

반응식

HRID 1250767 반응식
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:26][C:27](=[O:49])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([NH:39][CH2:40][CH2:41][CH2:42][N:43]1[CH2:48][CH2:47][O:46][CH2:45][CH2:44]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:26][C:27](=[O:49])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([NH:39][CH2:40][CH2:41][CH2:42][N:43]1[CH2:48][CH2:47][O:46][CH2:45][CH2:44]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

4

반응물 2

HCID 98092862-{3-[(3-Morpholinopropyl)amino]-3-oxopropyl}phenyl N-octadecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

생성물 1

HCID 18520278HCID 18520278, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

4N Hydrochloric acid/ethyl acetate solution (0.10 ml) was added to a solution containing 2-{3-[(3-morpholinopropyl)amino]-3-oxopropyl}phenyl N-octadecylcarbamate (0.20 g) in ethyl acetate (2 ml) while being cooled with ice. After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with ethyl acetate, thereby yielding the entitled compound (0.19 g) as white solid.

후처리

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with ethyl acetate

출처 및 근거

ORD 기록
ord-3eaea26ef3564063b69408a7b1fae71c
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06339154B1

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