Methanol → 6-Methyl-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carboxylic Acid, Methyl Ester

반응식

[NH2:1][C:2]1[C:3]([NH2:12])=[C:4]([C:8]([CH3:11])=[CH:9][CH:10]=1)[C:5]([O-:7])=[O:6].[C:13](OC)(=[O:18])[C:14](OC)=[O:15].[CH3:21]O>>[CH3:11][C:8]1[CH:9]=[CH:10][C:2]2[NH:1][C:14](=[O:15])[C:13](=[O:18])[NH:12][C:3]=2[C:4]=1[C:5]([O:7][CH3:21])=[O:6]

참가 물질

반응물 3

HCID 887Methanol

HCID 11120Dimethyl oxalate

HCID 18424114HCID 18424114, 화합물2회

생성물 1

HCID 108472796-Methyl-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carboxylic Acid, Methyl Ester

실험 절차

A solution of 2,3-diamino-6-methylbenzoic acid, methyl ester (compound 6) (1.14 g, 6.35 mmol) and dimethyl oxalate (3.34 g, 28.5 mmol) in MeOH (30 mL) was refluxed for 6 days. Upon cooling to room temperature, the precipitated product was collected and washed with a small amount of MeOH to give 1.02 g (69%).