Morpholine → 4-(1,3-Thiazol-2-yl)morpholine

반응식

Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>>[N:7]1([C:2]2[S:3][CH:4]=[CH:5][N:6]=2)[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 764302-Bromothiazole

생성물 1

HCID 154758374-(1,3-Thiazol-2-yl)morpholine수율 95%

반응 조건

온도: 100 °C

실험 절차

2-Bromothiazole (4.592 g) was added to morpholine (24 ml), and the mixture was stirred at 100° C. for 4 hr. The reaction mixture was partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried (over MgSO4) and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system) to give the title compound as a pale yellow oil (4.531 g, yield; 95%).

후처리

customThe reaction mixture was partitioned between ethyl acetate and water
washThe resulting organic layer was washed with water
dry with materialdried (over MgSO4)
customevaporated
customThe resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system)

출처 및 근거

ORD 기록: ord-ce19671af04d48fe811a37ff46e7b8ac
출처 데이터셋: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06340759B1

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