1-Ethylpiperazine → 6-Bromo-8-(1-ethylpiperazin-4-yl)-1,7-naphthyridine

HRID 1251157노트

반응식

HRID 1251157 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10](Br)[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[CH2:13]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:14]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([N:18]3[CH2:19][CH2:20][N:15]([CH2:13][CH3:14])[CH2:16][CH2:17]3)[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2

참가 물질

3

반응물 2

HCID 791961-EthylpiperazineHCID 225032286,8-Dibromo-1,7-naphthyridine

생성물 1

HCID 225032736-Bromo-8-(1-ethylpiperazin-4-yl)-1,7-naphthyridine수율 98%

반응 조건

온도
100 °C

실험 절차

6,8-Dibromo-1,7-naphthyridine (3.464 g) was added to 1-ethylpiperazine (10 ml), and the resulting mixture was stirred at 100° C. for 15 min. The reaction mixture was evaporated, and then partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried (over MgSO4) and evaporated. The resulting residue was purified by (NH) silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a yellowish orange solid (3.780 g, yield; 98%).

후처리

  1. customThe reaction mixture was evaporated
  2. custompartitioned between ethyl acetate and water
  3. washThe resulting organic layer was washed with water
  4. dry with materialdried (over MgSO4)
  5. customevaporated
  6. customThe resulting residue was purified by (NH) silica gel column chromatography (ethyl acetate/hexane system)

출처 및 근거

ORD 기록
ord-b62cc567fc674a359b050b04cd825e19
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06340759B1

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