Water → HCID 178510922, 화합물

HRID 1251179노트

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HRID 1251179 반응식
BrC[C:3]1[S:4][CH:5]=[CH:6][C:7]=1[C:8]#[N:9].[C-:10]#[N:11].[Na+].O.C(O[CH2:18][CH3:19])(=O)C>C1(C)C=CC=CC=1>[C:8]([CH2:7][CH2:6][C:5]1[SH:4]([C:10]#[N:11])[CH:3]=[CH:18][CH:19]=1)#[N:9]

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 8929Sodium CyanideHCID 225036202-(Bromomethyl)thiophene-3-carbonitrile

생성물 1

HCID 178510922HCID 178510922, 화합물수율 43%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

2-Bromomethyl-3-cyanothiophene (2.746 g) was dissolved in toluene (40 ml), followed by the addition of a solution of sodium cyanide (2.002 g)/water (15 ml), and the mixture was stirred at 80° C. overnight. The reaction mixture was diluted with ethyl acetate and washed with an aqueous solution of saturated sodium bicarbonate, dried (over MgSO4) and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a pale yellow solid (823 mg, yield; 43%).

후처리

  1. washwashed with an aqueous solution of saturated sodium bicarbonate
  2. dry with materialdried (over MgSO4)
  3. customevaporated
  4. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system)

출처 및 근거

ORD 기록
ord-cd10ed48ad1e4a63bc09b76fa715a435
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06340759B1

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