4-(Trifluoromethoxy)benzonitrile → 3-(4-Trifluoromethoxyphenyl)isoquinolin-1-one

HRID 1251205

반응식

HRID 1251205 반응식
[CH3:1][NH:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[F:12][C:13]([F:24])([F:23])[O:14][C:15]1[CH:22]=[CH:21][C:18](C#N)=[CH:17][CH:16]=1>>[F:12][C:13]([F:23])([F:24])[O:14][C:15]1[CH:22]=[CH:21][C:18]([C:1]2[NH:2][C:3](=[O:11])[C:4]3[C:5]([CH:10]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)=[CH:17][CH:16]=1

참가 물질

3

반응물 2

HCID 676214-(Trifluoromethoxy)benzonitrileHCID 75111N-methyl-2-toluamide

생성물 1

HCID 225032223-(4-Trifluoromethoxyphenyl)isoquinolin-1-one수율 24.9%

실험 절차

According to the method of Example 10-1, N-methyl-2-methylbenzamide (5.97 g) and 4-trifluoromethoxybenzonitrile (7.49 g) were reacted, to give 3-(4-trifluoromethoxyphenyl)isoquinolin-1-one (3.04 g).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-cf385812a43b4eb6bc6cf6b51c1c917d
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06340759B1

연결된 노트

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