Sulfuric Acid → (S)-4-hydroxy-3-methanesulfonyl hydroxybutyric acid

HRID 1251288노트

반응식

HRID 1251288 반응식
[CH3:1][S:2]([CH:5]1[CH2:10][O:9][C:7](=[O:8])[C@@H:6]1[OH:11])(=[O:4])=[O:3].S(=O)(=O)(O)[OH:13]>>[OH:9][CH2:10][CH:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C@@H:6]([OH:11])[C:7]([OH:13])=[O:8]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 86756702(S)-3-methanesulfonyl hydroxybutyrolactone

생성물 1

HCID 86756701(S)-4-hydroxy-3-methanesulfonyl hydroxybutyric acid

반응 조건

온도
50 °C

실험 절차

(S)-3-methanesulfonyl hydroxybutyrolactone (1.0 g, 5.6 mmol), D2O (10 ml), and the concentrated sulfuric acid (0.0549 g, 0.56 mmol) were placed in a 25 ml reactor and stirred at 50° C. for 3 hours. The reacting solution was cooled to room temperature and extracted with dichloromethane (10 ml) twice to recover the unreacted (S)-3-methanesulfonyl hydroxybutyrolactone. The presence of the target (S)-4-hydroxy-3-methanesulfonyl hydroxybutyric acid in a pure form in the D2O layer was confirmed by nuclear magnetic resonance.

후처리

  1. temperatureThe reacting solution was cooled to room temperature
  2. extractionextracted with dichloromethane (10 ml) twice
  3. customto recover the unreacted (S)-3-methanesulfonyl hydroxybutyrolactone

출처 및 근거

ORD 기록
ord-fa1edeb7b3a7497b9eb3a4fd0f567db3
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342034B1

반응 노트

불러오는 중…