Acetone Cyanohydrin → HCID 18323946, 화합물

HRID 1251370노트

반응식

HRID 1251370 반응식
[O-]S([O-])(=O)=O.[Mg+2].[CH3:7][C:8]([N:10](C)C)=O.[OH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[S:20]1[CH2:25][CH2:24]C(=O)[CH2:22][CH2:21]1.CC(C)(O)C#N>>[OH:13][CH:14]1[CH2:19][CH2:18][N:17]([C:7]2([C:8]#[N:10])[CH2:24][CH2:25][S:20][CH2:21][CH2:22]2)[CH2:16][CH2:15]1

참가 물질

6

반응물 5

HCID 6406Acetone CyanohydrinHCID 24083Sulfuric acid magnesium salt (1:1)HCID 31374DimethylacetamideHCID 66173Tetrahydrothiopyran-4-oneHCID 79341Piperidin-4-ol

생성물 1

HCID 18323946HCID 18323946, 화합물

실험 절차

It is prepared from MgSO4 (7.2 g, 60 mmoles), DMA (2.62 g, 30 mmoles), 4-hydroxy-piperidine (3.03 g, 20 mmoles), tetrahydro-4H-thiopyran-4-one (2.32 g, 20 mmoles) and acetone cyanhydrin (1.7 g, 20 mmoles). After treatment of the reaction, a white solid is obtained (4.7 g) which is crystallized from anhydrous ether. In this way, white crystals are obtained (3.6 g, 79%). M.p.=79-81° C.

후처리

  1. customAfter treatment of the reaction
  2. customa white solid is obtained (4.7 g) which
  3. customis crystallized from anhydrous ether
  4. customIn this way, white crystals are obtained (3.6 g, 79%)

출처 및 근거

ORD 기록
ord-eacb37ce01b34d108084f991eea0e370
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342511B1

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