4-Chlorophenyl phenyl ether → 4-(4-Chlorophenoxy)benzene-1-sulfonyl chloride

반응식

[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=1>>[Cl:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]2[CH:17]=[CH:16][C:15]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:14][CH:13]=2)=[CH:9][CH:8]=1

참가 물질

반응물 2

HCID 234364-Chlorophenyl phenyl ether

HCID 24638Chlorosulfonic acid

생성물 1

HCID 27577504-(4-Chlorophenoxy)benzene-1-sulfonyl chloride수율 33.4%

실험 절차

Chlorosulfonic acid (9.7 mL, 0.147 mole) was added dropwise to 4-chlorophenoxybenzene (12.6 mL, 73.4 mmole) at room temperature with stirring. When addition was complete, the mixture was stirred at room temperature for 1 hour and then poured into ice water. The solid was collected by filtration, dried in the air, and recrystallized from petroleum ether and ethyl acetate to give 4-(4-chlorophenoxy)benzenesulfonylchloride (7.43 grams, 33%).

후처리

additionWhen addition
stirringthe mixture was stirred at room temperature for 1 hour
filtrationThe solid was collected by filtration
customdried in the air
customrecrystallized from petroleum ether and ethyl acetate

출처 및 근거

ORD 기록: ord-21a63726e53f4437b5c51b92b937a607
출처 데이터셋: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06342521B1

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