2-Bromothiophene → 2-(3-methylphenyl)thiophene

HRID 1251771노트

반응식

Br[C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[CH3:7][C:8]1[CH:9]=[C:10](B(O)O)[CH:11]=[CH:12][CH:13]=1>>[C:8]1([CH3:7])[CH:9]=[CH:10][CH:11]=[C:12]([C:2]2[S:3][CH:4]=[CH:5][CH:6]=2)[CH:13]=1

참가 물질

반응물 2

HCID 138512-Bromothiophene

HCID 27339503-Tolylboronic acid

생성물 1

HCID 35641882-(3-methylphenyl)thiophene

실험 절차

2-(3-tolyl)thiophene was prepared in the same manner as described in Example 117A using 2-bromothiophene and 3-methylphenylboronic acid. The crude product was purified by flash chromatography on silica gel using hexane as the eluent (86% yield).

후처리

customThe crude product was purified by flash chromatography on silica gel

출처 및 근거

ORD 기록: ord-3d9ae6eed0b24c8296139aec1c5ec55d
출처 데이터셋: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06342610B2

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